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Recent research found that it can infect our cells using a protein called Niemann-Pick C1, which has become the target of anti-viral drugs.

(3.0 is technically a benzylpiperazine adamantine diamide molecule, and 3.47 is just like this molecule but has a methoxycarbonyl benzyl group added to it.) While the researchers (Cóté et al) found that their drugs bind NPC1, and that this can block Ebola infection, extensive pharmaceutical testing still needs to be done before doctors can use these drugs to fight Ebola infection in people.

For example, it needs to be determined whether the drugs bind other proteins that are similar to NPC1.

Next, you will investigate how even if a drug only binds its target protein, it may still disrupt delicate biological processes.

To do this we will look at the signaling pathways (biochemical pathways) that NPC1 and related proteins are involved in.

Determine how untested drugs may affect important biological processes that they were not intended to. Retrieved March 21, 2017 from Med_p011.shtml Recently, a breakthrough was made in our understanding of how the Ebola virus infects people.

Many outbreaks of the Ebola virus have occurred in Africa, and infection is often deadly. In August 2011, two different groups of researchers reported that in order to enter our cells and infect our bodies, the Ebola virus must bind to a protein called Niemann-Pick C1 ("NPC1" for short).

In this science project, using bioinformatics tools (computer tools used to explore biological processes), you will explore how these Ebola virus drugs could bind non-target proteins, that is, proteins other than NPC1, and how disrupting the normal function of NPC1 and these non-target proteins could interfere with normal cellular and bodily functions.

The questions that you will tackle here are exactly the ones researchers will be addressing, with the only difference being that researchers will be able to do both the bioinformatics work, what is covered in this science project, and testing of the resulting hypothesis in the lab.

Scientists recently found that some small drugs can stop infection by the deadly Ebola virus in its tracks.

Lab researchers found that these drugs bind to a protein that the Ebola virus uses to enter our cells, and this is how infection is prevented.

In this part of the science project you will be looking at what non-target proteins the Ebola drugs might interact with, based on how similar the target protein is to other proteins. The amino acid sequence of the protein will be located at the bottom of the protein page for the NPC1 protein.

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